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[From genetics to genomics in the rational design of new Mycobacterium tuberculosis vaccines].
- Source :
-
Enfermedades infecciosas y microbiologia clinica [Enferm Infecc Microbiol Clin] 2011 Oct; Vol. 29 (8), pp. 609-14. - Publication Year :
- 2011
-
Abstract
- Tuberculosis (TB) is an infectious disease affecting people from all ages all over the world. It is estimated that one third of the world population lives infected with the causal agent: Mycobacterium tuberculosis. Despite availability and systematic administration of BCG vaccine in endemic areas, TB transmission remains elusive to control, partly because BGC efficacy has been shown to have wide variability (0-80%). Such variability in protection is attributed to factors including: the BCG strain used for immunization, pre-existing exposure to environmental saprophytic Mycobacterium species, and host genetic factors. In this context, efforts regarding to re-engineering BCG vaccines with the ability to prevent latent TB reactivation, providing long lasting protection, and devoid from collateral effects in immunosuppressed people are urgent. In this work we review the actual molecular «gene-by-gene» strategies aimed at generating BCG alternatives, and discuss the urgent necessity of high throughput technology methods for a rational design for a new TB vaccine.<br /> (Copyright © 2010 Elsevier España, S.L. All rights reserved.)
- Subjects :
- Antigens, Bacterial immunology
BCG Vaccine
DNA, Bacterial genetics
DNA, Bacterial immunology
Drug Design
Epitopes immunology
Genes, Bacterial
Genetic Vectors genetics
Genetic Vectors immunology
Genomics
High-Throughput Screening Assays
Humans
Mycobacterium bovis genetics
Mycobacterium bovis immunology
Mycobacterium tuberculosis genetics
Vaccines, DNA
Vaccines, Subunit
Vaccines, Synthetic
Mycobacterium tuberculosis immunology
Tuberculosis Vaccines
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1578-1852
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Enfermedades infecciosas y microbiologia clinica
- Publication Type :
- Academic Journal
- Accession number :
- 21684635
- Full Text :
- https://doi.org/10.1016/j.eimc.2011.04.004