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[Animal experiment studies of the biological effect of artificial mineral fibers].
- Source :
-
Pneumologie (Stuttgart, Germany) [Pneumologie] 1990 Jul; Vol. 44 (7), pp. 846-9. - Publication Year :
- 1990
-
Abstract
- The extent of the pulmonary reaction to intensive exposure to dust is influenced by a number of factors, in particular the nature of the fibre, morphometry, solubility, duration of dust exposure, dust concentration, and, finally, the manufacturing process of the MMMF product and its chemical composition. The biological effect of the fibres on the lung is manifest by enhanced infiltration by macrophages and an increase in the number of neutrophils. In agreement with numerous published results, our own investigations failed to reveal any signs of a fibrogenic effect of MMMF. The reason for this is presumably the lack of biostability, the tendency of the fibres to fracture crosswise, and the much lower concentration of fibres in the critical length-diameter range. In contrast, MMMF have been shown to induce an irritation of the mucosa and the upper airways. With respect to possible long-term damage produced by MMMF from our own production, we have had no such experience to date.
- Subjects :
- Animals
Female
Lung pathology
Macrophages pathology
Male
Neutrophils pathology
Rats
Rats, Inbred Strains
Risk Factors
Swine
Swine, Miniature
Air Pollutants, Occupational adverse effects
Calcium Compounds
Dust adverse effects
Lung Neoplasms pathology
Pneumoconiosis pathology
Silicates
Silicic Acid adverse effects
Silicon Dioxide adverse effects
Subjects
Details
- Language :
- German
- ISSN :
- 0934-8387
- Volume :
- 44
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Pneumologie (Stuttgart, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 2169052