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Inhibitory effect of 1α-hydroxyvitamin D3 on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in Syrian hamsters.
- Source :
-
Acta medica Okayama [Acta Med Okayama] 2011 Jun; Vol. 65 (3), pp. 193-7. - Publication Year :
- 2011
-
Abstract
- Sixty-three male 5-week-old Syrian hamsters received the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) s.c. in 5 weekly injections (the first, 70 mg/kg body, and the remaining, 20mg/kg each). The hamsters that received BOP were given intragastric administration of 0.2 ml of medium chain triglyceride (MCT) with or without 0.04 μg of 1α-hydroxyvitamin D3 [1α(OH)D3] through a feeding tube for 12 weeks. Thus, 3 groups were assigned:Group 1;BOP alone (n=20), Group 2;BOP+MCT (n=18) and Group 3;BOP+1α(OH)D3 (n=25). The mean body weight of Group 3 was lower than those of Groups 1 and 2 at the end of the experiment (p<0.001,Tukey-Kramer HSD test). At the end of week 12, all surviving hamsters were put to sleep. The incidences of liver tumors were 80%, 72% and 32% in Groups 1, 2 and 3, respectively. The incidence of tumors in Group 3 was significantly lower than in Group 1 and Group 2 (p<0.05, χ2-test). All tumors were cholangiocarcinoma. These results indicated that BOP-induced cholangiocarcinogenesis was suppressed by the supplemental administration of 1α(OH)D3.
- Subjects :
- Animals
Bile Duct Neoplasms prevention & control
Carcinogens toxicity
Cholangiocarcinoma prevention & control
Cricetinae
Male
Mesocricetus
Antineoplastic Agents pharmacology
Bile Duct Neoplasms chemically induced
Bile Ducts, Intrahepatic pathology
Cholangiocarcinoma chemically induced
Cholecalciferol pharmacology
Nitrosamines toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0386-300X
- Volume :
- 65
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta medica Okayama
- Publication Type :
- Academic Journal
- Accession number :
- 21709717
- Full Text :
- https://doi.org/10.18926/AMO/46631