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Plasmacytoma-like post-transplant lymphoproliferative disorder, a rare subtype of monomorphic B-cell post-transplant lymphoproliferation, is associated with a favorable outcome in localized as well as in advanced disease: a prospective analysis of 8 cases.
- Source :
-
Haematologica [Haematologica] 2011 Jul; Vol. 96 (7), pp. 1067-71. - Publication Year :
- 2011
-
Abstract
- Post-transplantation lymphoproliferative disorder (PTLD) with plasmacellular differentiation has been reported as a rare subtype of monomorphic B-cell post-transplant lympho-proliferation with histological and immunophenotypical features of plasmacytoma in the non-transplant population. Here we present clinical, laboratory and histopathological features, treatment and outcome of 8 patients from the German prospective PTLD registry. Clinically, extranodal manifestations were common while osteolytic lesions were rare and none of the patients had bone marrow involvement. Immunohistochemistry showed light chain restriction and expression of CD138 without CD20 expression in all samples. An association with Epstein-Barr virus was found in 3 out of 8 cases. We suggest that the Ann Arbor classification is most useful for this disease entity and report a generally good response to treatment including reduction of immuno-suppression, surgery and irradiation in localized disease and systemic chemotherapy analogous to plasmacell myeloma in advanced disease.
- Subjects :
- Adult
Aged
Antigens, CD metabolism
B-Lymphocytes virology
DNA, Viral blood
Epstein-Barr Virus Infections complications
Epstein-Barr Virus Infections diagnosis
Female
Herpesvirus 4, Human physiology
Humans
Male
Middle Aged
Neoplasm Staging
Plasmacytoma complications
Plasmacytoma virology
Transplantation Conditioning adverse effects
Treatment Outcome
Young Adult
B-Lymphocytes metabolism
B-Lymphocytes pathology
Organ Transplantation adverse effects
Plasmacytoma pathology
Plasmacytoma therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1592-8721
- Volume :
- 96
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 21719885
- Full Text :
- https://doi.org/10.3324/haematol.2010.039214