The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells.

Authors :: Redfern CP
Daly AK
Latham JA
Todd C
Source :: FEBS letters [FEBS Lett] 1990 Oct 29; Vol. 273 (1-2), pp. 19-22.
Publication Year :: 1990
Abstract: The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.

Subjects :: Animals
Carrier Proteins biosynthesis
Cell Line
Cycloheximide pharmacology
Kinetics
Melanoma, Experimental
Mice
RNA, Messenger genetics
RNA, Messenger isolation & purification
Receptors, Retinoic Acid
Stereoisomerism
Tretinoin analogs & derivatives
Carrier Proteins genetics
Gene Expression drug effects
Tretinoin pharmacology

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