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Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats.
- Source :
-
Natural product research [Nat Prod Res] 2011 Jul; Vol. 25 (11), pp. 1110-4. - Publication Year :
- 2011
-
Abstract
- Nerium oleander Linn. (NO), an evergreen shrub, is used in folklore medicine as a cardiotonic and exhibits a wide spectrum of bioactivities. Herein, the hypolipidemic potential of the ethanolic extract of flowers of Nerium oleander (ENO) in a minimal dose was assessed. A high fat diet (HFD) resulted in a significant increase in cardiac lipids and lipoproteins and an increase in body weight gain. Simultaneous treatment with ENO significantly lowered the increase in body weight gain, lipid and lipoprotein levels, with a concomitant increase in HDL in the plasma and heart when compared to HFD-fed rats. Likewise, the activities of lipolytic enzymes were also upheld by the ENO treatment in the heart compared to HFD-fed rats. The above findings highlight the possible mechanism of N. oleander as a hypolipidemic agent in its use in folklore medicine as a cardiotonic.
- Subjects :
- Animals
Atorvastatin
Heptanoic Acids therapeutic use
Hypolipidemic Agents chemistry
Lipoproteins metabolism
Plant Extracts chemistry
Pyrroles therapeutic use
Rats
Rats, Sprague-Dawley
Weight Gain drug effects
Dietary Fats adverse effects
Flowers chemistry
Hypolipidemic Agents pharmacology
Nerium chemistry
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 21726133
- Full Text :
- https://doi.org/10.1080/14786419.2010.541883