GABA(A) receptor- and GABA transporter polymorphisms and risk for essential tremor.

Authors :: Thier S
Kuhlenbäumer G
Lorenz D
Nothnagel M
Nebel A
Christensen K
Schreiber S
Deuschl G
Klebe S
Source :: European journal of neurology [Eur J Neurol] 2011 Aug; Vol. 18 (8), pp. 1098-100. Date of Electronic Publication: 2010 Dec 22.
Publication Year :: 2011
Abstract: Background: Clinical features and animal models of essential tremor (ET) suggest gamma-aminobutyric acid A receptor (GABA(A) R) subunits and GABA transporters as putative candidate genes.<br />Methods: A total of 503 ET cases and 818 controls were investigated for an association between polymorphisms in 15 GABA(A) R and four GABA transporter genes and ET.<br />Results: Nine nominally significant tagging SNPs (P values from 4.9×10(-2) to 5.2×10(-4) ) were found in the hypothesis generation stage. Five SNPs were followed up in a second verification stage but failed to reach significance. (P values from 0.30 to 0.77).<br />Discussion: In our samples, no evidence of association between GABA(A) R and GABA transporter genes with ET was detected. Further studies are necessary to clarify the role of these genes in ET.<br /> (© 2010 The Author(s). European Journal of Neurology © 2010 EFNS.)

Subjects :: Adult
Aged
Aged, 80 and over
Case-Control Studies
Essential Tremor epidemiology
Essential Tremor metabolism
Female
Genetic Predisposition to Disease epidemiology
Humans
Male
Middle Aged
Risk Factors
Young Adult
gamma-Aminobutyric Acid physiology
Essential Tremor genetics
GABA Plasma Membrane Transport Proteins genetics
Genetic Predisposition to Disease genetics
Polymorphism, Single Nucleotide genetics
Receptors, GABA-A genetics

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