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New side effect of the hypoxic cell sensitizer, misonidazole.

Authors :
Partington J
Koziol D
Chapman D
Rabin H
Urtasun RC
Source :
Cancer treatment reports [Cancer Treat Rep] 1979 Jan; Vol. 63 (1), pp. 123-5.
Publication Year :
1979

Abstract

As part of a phase II study with the hypoxic cell radiosensitizer, misonidazole, we have encountered two cases of dermatitis. When all drugs were withdrawn and the patients were challenged with a small single dose of misonidazole, identical adverse reactions reappeared demonstrating a drug-related skin hypersensitivity.

Subjects

Subjects :
Aged
Brain Neoplasms drug therapy
Drug Therapy, Combination
Female
Glioblastoma drug therapy
Humans
Male
Misonidazole blood
Misonidazole therapeutic use
Drug Eruptions etiology
Misonidazole adverse effects
Nitroimidazoles adverse effects

Details

Language :
English
ISSN :
0361-5960
Volume :
63
Issue :
1
Database :
MEDLINE
Journal :
Cancer treatment reports
Publication Type :
Academic Journal
Accession number :
217536

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Authors Abstract Subjects Details