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Polymorphisms in CCR6 are associated with chronic graft-versus-host disease and invasive fungal disease in matched-related hematopoietic stem cell transplantation.
- Source :
-
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2011 Oct; Vol. 17 (10), pp. 1443-9. Date of Electronic Publication: 2011 Jul 18. - Publication Year :
- 2011
-
Abstract
- Graft-versus-host disease (GVHD) and fungal infections are frequent complications after allogeneic hematopoietic stem cell transplantation (HSCT). Single nucleotide polymorphisms (SNPs) in genes of the immune system can influence the inflammatory cascade and T cell-driven alloimmune reactions after HSCT, and thus increasing the incidence of GVHD and infectious complications. Here, we investigated the effect of SNPs in IL-23R and CCR6 on posttransplantation outcome in 161 recipients of partially T cell-depleted HSCT. Remarkably, IL-23R SNPs were not associated with clinical outcome, but we found that disparities in the CCR6 tagSNP rs2301436 and SNP rs3093023 are independently associated with the occurrence of chronic GVHD (cGVHD) and invasive fungal disease. In multivariate analysis, patients receiving a transplant from a homozygous rs2301436 G allele donor showed less cGVHD (odds ratio [OR]: 0.16; P = .002), as was the case for a homozygous donor rs3093023 G allele (OR: 0.24; P = .005). In parallel, the GG genotype at rs2301436 in donors was associated with a higher incidence of invasive fungal disease at day 100 after HSCT (OR: 3.59; P = .008). This study shows that CCR6 SNPs can be used to predict clinical outcome, and that polymorphisms in the CCR6 gene may influence T cell-mediated immune reactions after HSCT.<br /> (Copyright © 2011 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Alleles
Chronic Disease
Genotype
Graft vs Host Disease immunology
Hematologic Neoplasms genetics
Hematologic Neoplasms immunology
Hematologic Neoplasms therapy
Humans
Immunity, Cellular genetics
Immunity, Cellular immunology
Male
Middle Aged
Mycoses immunology
Netherlands
Receptors, CCR6 immunology
Receptors, Interleukin genetics
Receptors, Interleukin immunology
T-Lymphocytes immunology
Transplantation, Homologous
Graft vs Host Disease genetics
Hematopoietic Stem Cell Transplantation
Mycoses genetics
Polymorphism, Single Nucleotide
Receptors, CCR6 genetics
Unrelated Donors
Subjects
Details
- Language :
- English
- ISSN :
- 1523-6536
- Volume :
- 17
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 21763254
- Full Text :
- https://doi.org/10.1016/j.bbmt.2011.07.004