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Different pathological roles of toll-like receptor 9 on mucosal B cells and dendritic cells in murine IgA nephropathy.
- Source :
-
Clinical & developmental immunology [Clin Dev Immunol] 2011; Vol. 2011, pp. 819646. Date of Electronic Publication: 2011 Jun 30. - Publication Year :
- 2011
-
Abstract
- Although pathogenesis of IgA nephropathy (IgAN) is still obscure, pathological contribution of mucosal immunity including production of nephritogenic IgA and IgA immune complex (IC) has been discussed. We have reported that mucosal toll-like receptor (TLR)-9 is involved in the pathogenesis of human and murine IgAN. However, cell-type expressing TLR9 in mucosa remains unclear. To address this, we nasally challenged cell-specific CpG DNA ((i): dendritic cell: (DC), (ii): B cell, (iii): both), known as ligand for TLR9, to IgAN prone mice and analyzed disease phenotype of each group. After 8 times of the weekly administration, every group showed deterioration of glomerular damage. However, CpG-A-group showed clear extension of mesangial proliferative lesions with increase of serum IgA-IgG2a IC and its glomerular depositions, while CpG-B-group showed extent of glomerular sclerotic lesions with increase of serum and glomerular IgA and M2 macrophage infiltration. Present results indicate that mucosal TLR9 on B cells and DC may differently contribute to the progression of this disease via induction of nephritogenic IgA or IgA-IgG IC, respectively. This picture is suggestive for the pathological difference between child and adult IgAN.
- Subjects :
- Administration, Intranasal
Adult
Animals
Antigen-Antibody Complex blood
Antigen-Antibody Complex immunology
B-Lymphocytes immunology
B-Lymphocytes pathology
Child
CpG Islands genetics
CpG Islands immunology
Dendritic Cells immunology
Dendritic Cells pathology
Disease Models, Animal
Disease Progression
Female
Glomerulonephritis, IGA blood
Glomerulonephritis, IGA genetics
Humans
Immunoglobulin A blood
Immunoglobulin G blood
Kidney Glomerulus drug effects
Kidney Glomerulus pathology
Mice
Mice, Inbred Strains
Mucous Membrane immunology
Mucous Membrane pathology
Oligonucleotides pharmacology
Sclerosis
B-Lymphocytes drug effects
Dendritic Cells drug effects
Glomerulonephritis, IGA immunology
Glomerulonephritis, IGA pathology
Immunity, Mucosal
Immunoglobulin A immunology
Immunoglobulin G immunology
Mucous Membrane drug effects
Toll-Like Receptor 9 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1740-2530
- Volume :
- 2011
- Database :
- MEDLINE
- Journal :
- Clinical & developmental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21765852
- Full Text :
- https://doi.org/10.1155/2011/819646