Antifungal susceptibility of Candida albicans in biofilms.

Authors :: Tobudic S
Kratzer C
Lassnigg A
Presterl E
Source :: Mycoses [Mycoses] 2012 May; Vol. 55 (3), pp. 199-204. Date of Electronic Publication: 2011 Jul 28.
Publication Year :: 2012
Abstract: Candida albicans are the most common fungi associated with biofilm-related infections. Biofilms are defined as microbial communities encased in a matrix of extracellular polymeric substances. The most important feature of biofilm growth is the high resistance to antimicrobial agents that can be up to 1000-fold greater than that of planktonic cells. This review discusses the factors affecting antifungal resistance as well as activity of mono- and combination therapy of different antifungal classes and antifungal activity in vitro and in vivo against C. albicans biofilms.<br /> (© 2011 Blackwell Verlag GmbH.)