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Deaths associated with human adenovirus-14p1 infections, Europe, 2009-2010.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2011 Aug; Vol. 17 (8), pp. 1402-8. - Publication Year :
- 2011
-
Abstract
- Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
- Subjects :
- Adenovirus E1A Proteins genetics
Adenovirus Infections, Human virology
Adenoviruses, Human immunology
Adenoviruses, Human isolation & purification
Adult
Antibodies, Viral blood
Capsid Proteins genetics
Cell Line, Tumor
Child, Preschool
Communicable Diseases, Emerging virology
Europe epidemiology
Female
Humans
Infant
Infant, Newborn
Ireland epidemiology
Male
Middle Aged
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Respiratory Tract Infections virology
Sequence Analysis, DNA
Serotyping
Survival Analysis
United States epidemiology
Virus Cultivation
Adenovirus Infections, Human mortality
Adenoviruses, Human classification
Adenoviruses, Human genetics
Communicable Diseases, Emerging mortality
Respiratory Tract Infections mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21801616
- Full Text :
- https://doi.org/10.3201/eid1708.101760