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Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test.
- Source :
-
Behavioural brain research [Behav Brain Res] 2011 Nov 20; Vol. 225 (1), pp. 328-33. Date of Electronic Publication: 2011 Jul 23. - Publication Year :
- 2011
-
Abstract
- Clinical and preclinical data reported that ascorbic acid has antidepressant properties. The present study was designed to investigate the participation of l-arginine-NO-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test (TST) in mice. The antidepressant-like effect of ascorbic acid (1mg/kg, p.o.) in the TST was prevented by the pre-treatment of mice with NMDA (0.1pmol/site, i.c.v.), l-arginine (750mg/kg, i.p., a substrate for nitric oxide synthase) or sildenafil (5mg/kg, i.p., a phosphodiesterase 5 inhibitor). The administration of MK-801 (0.001mg/kg, i.p), 7-nitroindazole (25mg/kg, i.p., a neuronal nitric oxide synthase inhibitor) or ODQ (30pmol/site i.c.v., a soluble guanylate cyclase inhibitor) in combination with a sub-effective dose of ascorbic acid (0.1mg/kg, p.o.) reduced the immobility time in the TST test when compared with either drug alone. None of the results in the TST appears to be due to a nonspecific locomotor effect. Our findings provide evidence that the effect of ascorbic acid in the TST involve an interaction with NMDA receptors and l-arginine-NO-cGMP pathway, contributing to the understanding of the mechanisms underlying the antidepressant-like effect of this vitamin.<br /> (Copyright © 2011. Published by Elsevier B.V.)
- Subjects :
- Animals
Arginine pharmacology
Ascorbic Acid pharmacology
Depression diagnosis
Disease Models, Animal
Dizocilpine Maleate pharmacology
Enzyme Inhibitors pharmacology
Exploratory Behavior drug effects
Female
Hindlimb Suspension physiology
Indazoles pharmacology
Mice
N-Methylaspartate pharmacology
Oxadiazoles pharmacology
Piperazines pharmacology
Purines pharmacology
Quinoxalines pharmacology
Signal Transduction drug effects
Sildenafil Citrate
Sulfones pharmacology
Antidepressive Agents therapeutic use
Ascorbic Acid therapeutic use
Cyclic GMP metabolism
Depression drug therapy
Hindlimb Suspension methods
Nitric Oxide metabolism
Signal Transduction physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 225
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 21802450
- Full Text :
- https://doi.org/10.1016/j.bbr.2011.07.024