Determination of photostability and photodegradation products of indomethacin in aqueous media.

Authors :: Temussi F
Cermola F
Dellagreca M
Iesce MR
Passananti M
Previtera L
Zarrelli A
Source :: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2011 Dec 05; Vol. 56 (4), pp. 678-83. Date of Electronic Publication: 2011 Jul 12.
Publication Year :: 2011
Abstract: Photochemical behaviour of indomethacin in aqueous media at 254nm, 310nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)

Subjects :: Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal metabolism
Drug Stability
Humans
Hydrolysis
Indomethacin chemistry
Indomethacin metabolism
Oxidation-Reduction
Pharmacokinetics
Photosensitivity Disorders metabolism
Solvents
Sunlight
Ultraviolet Rays
Water Pollutants, Chemical analysis
Water Pollutants, Chemical chemistry
Water Pollutants, Chemical metabolism
Anti-Inflammatory Agents, Non-Steroidal analysis
Indomethacin analysis
Photolysis

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