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Increased mortality among publicly insured participants in the HIV Outpatient Study despite HAART treatment.
- Source :
-
AIDS (London, England) [AIDS] 2011 Sep 24; Vol. 25 (15), pp. 1865-76. - Publication Year :
- 2011
-
Abstract
- Objective: Understanding mortality differences among HIV-infected patients can focus efforts to improve survival.<br />Design: We evaluated death rates, causes, and associated factors among treated patients in the HIV Outpatient Study (HOPS), a large, prospective, multicenter observational cohort of HIV-infected persons seen at a diverse set of US sites of care.<br />Methods: Among 3754 HOPS participants seen during 1996-2007 with at least 6 months of follow-up after initiating HAART and receiving HAART at least 75% of time under observation ('substantially treated'), we calculated hazard ratios for death using proportional hazards regression models. We also examined death causes and comorbidities among decedents.<br />Results: Substantially treated participants, followed a median 4.7 years (interquartile range, 2.2-8.5), experienced 331 deaths. In multivariable analyses, higher mortality was associated with an index CD4 cell count less than 200 cells/μl [adjusted hazard ratio (aHR), 2.86; 95% confidence interval (CI) 1.95-4.21], older age (aHR, 1.50 per 10 years; 95% CI 1.33-1.70), log(10)HIV RNA (aHR, 1.67 per log(10); 95% CI 1.51-1.85), but not race/ethnicity (aHR, 0.99 for blacks vs. whites, P = 0.92). Mortality was increased among publicly insured (PUB) vs. privately insured participants (PRV) when index CD4 cell count was at least 200 cells/μl (aHR, 2.03; 95% CI 1.32-3.14) but not when index CD4 cell count was less than 200 cells/μl (aHR, 1.3, P = 0.13). By death cause, PUB had significantly more cardiovascular events and hepatic disorders than PRV. Comorbidities more frequent among PUB vs. PRV decedents included cardiovascular disease, renal impairment, and chronic hepatitis.<br />Conclusion: Among HAART-treated participants with CD4 cell counts at least 200 cells/μl, PUB experienced higher death rates than PRV. Non-AIDS death and disease causes predominated among publicly insured decedents, suggesting that treatable comorbidities contributed to survival disparities.
- Subjects :
- Adult
CD4 Lymphocyte Count
Comorbidity
Female
HIV Infections drug therapy
Humans
Male
Middle Aged
Odds Ratio
Outpatients statistics & numerical data
Proportional Hazards Models
Prospective Studies
Survival Analysis
United States epidemiology
Antiretroviral Therapy, Highly Active
HIV Infections mortality
Insurance, Health statistics & numerical data
Public Sector
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 25
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21811144
- Full Text :
- https://doi.org/10.1097/QAD.0b013e32834b3537