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No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.
- Source :
-
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2011 Dec; Vol. 156B (7), pp. 764-71. Date of Electronic Publication: 2011 Aug 02. - Publication Year :
- 2011
-
Abstract
- We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.<br /> (Copyright © 2011 Wiley-Liss, Inc.)
Details
- Language :
- English
- ISSN :
- 1552-485X
- Volume :
- 156B
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 21812096
- Full Text :
- https://doi.org/10.1002/ajmg.b.31216