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Tanshinone IIA prevents cardiac remodeling through attenuating NAD (P)H oxidase-derived reactive oxygen species production in hypertensive rats.
- Source :
-
Die Pharmazie [Pharmazie] 2011 Jul; Vol. 66 (7), pp. 517-24. - Publication Year :
- 2011
-
Abstract
- Tanshinone IIA is one of major constituents of Salvia miltiorrhiza Bunge known as Danshen. Our and others' studies have shown that Tan IIA could protect cardimyocyte against apoptosis; however the effect of Tan IIA on cardiac remodeling disease is still unknown. In this study, we investigated the effects of Tan IIA on cardiac hypertrophy and fibrosis in two-kidney, two-clip (2K2C) hypertensive rats and by which, if any, mechanisms. Administration of 2K2C hypertensive rats with Tan IIA attenuated cardiac dysfunction and fibrosis. However Tan IIA treatment had no effects on BP control. Further studies revealed that Tan IIA inhibited the increased NAD(P)H oxidase activity and expression as well as O2*- production in 2K2C hypertensive rats. Our results indicated that Tan IIA significantly improved cardiac function and attenuated fibrosis in 2K2C hypertensive rats. The protective action of Tan IIA is likely mediated by its antioxidant effect, independent of BP control, partially via inhibiting NADPH oxidase.
- Subjects :
- Animals
Blotting, Western
Cardiomegaly metabolism
Cardiomegaly pathology
Coronary Circulation drug effects
Fibrosis
Heart Diseases diagnostic imaging
Heart Diseases prevention & control
Hemodynamics drug effects
Hypertension, Renovascular metabolism
Male
Myocardium pathology
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Stroke Volume drug effects
Ultrasonography
Ventricular Dysfunction, Left pathology
Ventricular Dysfunction, Left prevention & control
Abietanes pharmacology
Cardiomegaly prevention & control
Cardiotonic Agents
Enzyme Inhibitors
Hypertension, Renovascular pathology
NADPH Oxidases antagonists & inhibitors
Reactive Oxygen Species metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7144
- Volume :
- 66
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 21812327