Back to Search
Start Over
Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project.
- Source :
-
Environmental health perspectives [Environ Health Perspect] 2011 Dec; Vol. 119 (12), pp. 1760-5. Date of Electronic Publication: 2011 Aug 03. - Publication Year :
- 2011
-
Abstract
- Background: People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities.<br />Objectives: Our objective was to estimate historical PFOA exposures and serum concentrations experienced by 45,276 non-occupationally exposed participants in the C8 Health Project who consented to share their residential histories and a 2005-2006 serum PFOA measurement.<br />Methods: We estimated annual PFOA exposure rates for each individual based on predicted calibrated water concentrations and predicted air concentrations using an environmental fate and transport model, individual residential histories, and maps of public water supply networks. We coupled individual exposure estimates with a one-compartment absorption, distribution, metabolism, and excretion (ADME) model to estimate time-dependent serum concentrations.<br />Results: For all participants (n = 45,276), predicted and observed median serum concentrations in 2005-2006 are 14.2 and 24.3 ppb, respectively [Spearman's rank correlation coefficient (r(s)) = 0.67]. For participants who provided daily public well water consumption rate and who had the same residence and workplace in one of six municipal water districts for 5 years before the serum sample (n = 1,074), predicted and observed median serum concentrations in 2005-2006 are 32.2 and 40.0 ppb, respectively (r(s) = 0.82).<br />Conclusions: Serum PFOA concentrations predicted by linked exposure and ADME models correlated well with observed 2005-2006 human serum concentrations for C8 Health Project participants. These individualized retrospective exposure and serum estimates are being used in a variety of epidemiologic studies being conducted in this region.
- Subjects :
- Drinking Water analysis
Environmental Monitoring methods
Female
Humans
Infant
Infant, Newborn
Male
Ohio
Retrospective Studies
West Virginia
Caprylates blood
Environmental Exposure statistics & numerical data
Environmental Monitoring statistics & numerical data
Environmental Pollutants blood
Fluorocarbons blood
Models, Theoretical
Subjects
Details
- Language :
- English
- ISSN :
- 1552-9924
- Volume :
- 119
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Environmental health perspectives
- Publication Type :
- Academic Journal
- Accession number :
- 21813367
- Full Text :
- https://doi.org/10.1289/ehp.1103729