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Antipsychotic drug administration does not correlate with prolonged rate-corrected QT interval in children and adolescents: results from a nested case-control study.
- Source :
-
Journal of child and adolescent psychopharmacology [J Child Adolesc Psychopharmacol] 2011 Aug; Vol. 21 (4), pp. 365-8. Date of Electronic Publication: 2011 Aug 08. - Publication Year :
- 2011
-
Abstract
- Background: The rate-corrected QT interval (QTc) prolongation is a risk factor for sudden cardiac death and may be induced by antipsychotic drugs.<br />Objective: To determine the clinical characteristics associated with QTc prolongation (440 msec or greater) in children and adolescents hospitalized for treatment of psychiatric disorders.<br />Method: We determined the frequency of baseline prolongation of QTc in 811 psychiatric pediatric inpatients (15.5 ± 2.4 years of age). QTc duration was 440 msec or greater (range 441-481 msec) in 16 patients (1.97%). In a 1:5 nested case-control design, the 16 patients with prolonged QTc were age- and gender-matched with 80 patients with QTc of <421 msec.<br />Results: Patients with normal and prolonged QTc had similar utilization of antipsychotics (43.8% vs. 40.8%) and daily chlorpromazine equivalents (165 ± 110 vs. 168 ± 218 mg). Hypokalemia (p = 0.009) and obesity (p = 0.032) were more common among patients with prolonged QTc. The correlation between obesity and QTc prolongation was confirmed in logistic regression analysis.<br />Conclusions: In a large cohort of youth hospitalized for treatment of psychiatric disorders, a prolonged QTc on admission was rare and correlated with the presence of obesity, but not with current use of antipsychotic drugs.
- Subjects :
- Adolescent
Anti-Anxiety Agents therapeutic use
Antipsychotic Agents administration & dosage
Antipsychotic Agents therapeutic use
Arrhythmias, Cardiac chemically induced
Case-Control Studies
Child
Cohort Studies
Death, Sudden, Cardiac etiology
Death, Sudden, Cardiac pathology
Electrocardiography
Female
Humans
Hypokalemia pathology
Long QT Syndrome chemically induced
Male
Mental Disorders diagnosis
Mental Disorders pathology
Obesity pathology
Risk Factors
Schizophrenia drug therapy
Antipsychotic Agents adverse effects
Heart Rate drug effects
Mental Disorders drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8992
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of child and adolescent psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21823910
- Full Text :
- https://doi.org/10.1089/cap.2011.0024