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IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells.
- Source :
-
Immunology letters [Immunol Lett] 2011 Dec 30; Vol. 141 (1), pp. 61-7. Date of Electronic Publication: 2011 Jul 30. - Publication Year :
- 2011
-
Abstract
- The IL-22 NKp46(+) innate lymphoid cells, NCR22 cells, are very important for the early host defense against microbial pathogens. We show here that NCR22 cells were differentiated from Lin(-)CD127(+)CD117(+) cells that were derived from hematopoietic precursor cells (HPCs) of mouse bone marrow cells. The combination of low concentrations of IL-23 and IL-15 induced differentiation of NCR22 cells from Lin(-)CD127(+)CD117(+) cells. NCR22 cells expressed a large amount of IL-22 and RORγt, and they had poor cytolytic activity and produced little IFN-γ. Lin(-)CD127(+)CD117(+) cells were very similar to intestinal lamina propria LTi-like cells; both cells dominantly expressed RORγt and IL-22. Meanwhile, Lin(-)CD127(-)CD117(+) cells that were also derived from HPCs did not express RORγt and IL-22, and they developed into conventional NK cells, not into NCR22 cells. These findings revealed that NCR22 cells can be differentiated from Lin(-)CD127(+)CD117(+) cells which are derived from HPCs.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Female
Hematopoietic Stem Cells metabolism
Interleukin-15 immunology
Interleukin-15 metabolism
Interleukin-23 metabolism
Interleukin-7 Receptor alpha Subunit metabolism
Intestinal Mucosa metabolism
Lymphocytes metabolism
Mice
Mice, Inbred Strains
Mice, Knockout
Proto-Oncogene Proteins c-kit metabolism
Interleukin-22
Antigens, Ly metabolism
Cell Differentiation physiology
Interleukins biosynthesis
Killer Cells, Natural cytology
Killer Cells, Natural metabolism
Natural Cytotoxicity Triggering Receptor 1 metabolism
Nuclear Receptor Subfamily 1, Group F, Member 3 biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0542
- Volume :
- 141
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 21835206
- Full Text :
- https://doi.org/10.1016/j.imlet.2011.07.007