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Trade-offs between elimination and detoxification in rainbow trout and common bivalve molluscs exposed to metal stressors.
- Source :
-
Chemosphere [Chemosphere] 2011 Oct; Vol. 85 (6), pp. 1048-56. Date of Electronic Publication: 2011 Aug 12. - Publication Year :
- 2011
-
Abstract
- The purpose of this paper was to examine trade-offs between elimination and detoxification in rainbow trout and three common bivalve molluscs (clam, oyster, and scallop) exposed to cadmium (Cd), copper (Cu), and zinc (Zn) based on recent reported experimental data. We incorporated metal influx threshold with subcellular partitioning to estimate rate constants of detoxification (k(d)) and elimination (k₂). We found that the relationships between k₂ and k(d) were negative for rainbow trout and positive for bivalve molluscs. However, the relationships between k(d) and % metal in metabolically detoxified pool were found positive for rainbow trout and negative for bivalve molluscs. Our results also indicated that rainbow trout had higher accumulation (~60-90%) in metabolically active pool when exposed to essential metals of Cu and Zn and had only 10-50% accumulation in response to non-essential metal of Cd. Based on a cluster analysis, this study indicated that similarity of physiological regulations among study species was found between Cd and Zn. Our study suggested that detoxification can be predicted by an elimination-detoxification scheme with the known elimination rate constant. We concluded that quantification of trade-offs between subcellular partitioning and detoxification provides valuable insights into the ecotoxicology of aquatic organisms and enhances our understanding of the subcellular biology of trace metals.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Bivalvia cytology
Bivalvia physiology
Cluster Analysis
Ecotoxicology
Inactivation, Metabolic
Intracellular Space drug effects
Intracellular Space metabolism
Oncorhynchus mykiss physiology
Water Pollutants, Chemical pharmacokinetics
Water Pollutants, Chemical toxicity
Bivalvia drug effects
Bivalvia metabolism
Environmental Exposure adverse effects
Metals, Heavy pharmacokinetics
Metals, Heavy toxicity
Oncorhynchus mykiss metabolism
Stress, Physiological drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1298
- Volume :
- 85
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Chemosphere
- Publication Type :
- Academic Journal
- Accession number :
- 21840032
- Full Text :
- https://doi.org/10.1016/j.chemosphere.2011.07.033