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Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria.

Authors :
Prescott TA
Veitch NC
Simmonds MS
Source :
Journal of ethnopharmacology [J Ethnopharmacol] 2011 Oct 11; Vol. 137 (3), pp. 1306-10. Date of Electronic Publication: 2011 Aug 06.
Publication Year :
2011

Abstract

Ethnopharmacological Relevance: Teucrium chamaedrys L. and Nepeta cataria L. (Lamiaceae) are species with traditional uses that relate to the treatment of inflammation. Extracts of both species were found to inhibit calcineurin; an important regulator of T-cell mediated inflammation that has received little attention in ethnopharmacological research.<br />Materials and Methods: Extracts and isolated compounds were tested against calcineurin in its calmodulin-activated and basal un-activated state. Active compounds were isolated using Sephadex LH-20 gel filtration and HPLC then identified using NMR spectroscopy.<br />Results and Conclusions: Activity-guided fractionation of Teucrium chamaedrys and Nepeta cataria led to the isolation of the caffeoyl phenylethanoid glycosides teucrioside, verbascoside and lamiuside A (teupolioside). The three compounds inhibited calcineurin both in the presence and absence of calmodulin, suggesting a direct interaction with calcineurin. Calcineurin inhibition should be considered as a potential mode of action when investigating the immunomodulatory activity of caffeoyl phenylethanoid glycoside containing plants.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1872-7573
Volume :
137
Issue :
3
Database :
MEDLINE
Journal :
Journal of ethnopharmacology
Publication Type :
Academic Journal
Accession number :
21843624
Full Text :
https://doi.org/10.1016/j.jep.2011.07.063