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Patients 35 years old or younger with operable breast cancer are more at risk for relapse and survival: a retrospective matched case-control study.
- Source :
-
Breast (Edinburgh, Scotland) [Breast] 2011 Dec; Vol. 20 (6), pp. 568-73. Date of Electronic Publication: 2011 Aug 16. - Publication Year :
- 2011
-
Abstract
- It has long been suggested that younger women with breast cancer have less favorable prognostic factors and poorer outcomes. Our main objectives were to determine whether poor prognosis among young women was independent of other common clinicopathologic parameters. We retrospectively analyzed 551 young patients (≤ 35 years, Group I) and 551 older patients (36-50 years, Group II), matched for year of diagnosis, family history of breast cancer, pathologic stage, hormone receptor expression and application of adjuvant therapy. Patients in Group I had significantly shorter disease-free survival (DFS) than Group II (median 23.2 months vs. 28.4 months, P = 0.024). Five-year DFS rate(63.7% vs. 74.7%, P < 0.001) and overall survival (OS) rate (79.5% vs. 85.6%, P = 0.024) in Group I was inferior to those in Group II. Multivariate analysis showed that young age was a significantly negative predictor for DFS and OS. Our study thus shows that age (≤ 35 y/o) is an independent risk factor for prognosis in operable breast cancer.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Age Factors
Breast Neoplasms mortality
Breast Neoplasms pathology
Case-Control Studies
China
Disease-Free Survival
Female
Humans
Middle Aged
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local pathology
Retrospective Studies
Risk Factors
Young Adult
Breast Neoplasms surgery
Neoplasm Recurrence, Local surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3080
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Breast (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 21843944
- Full Text :
- https://doi.org/10.1016/j.breast.2011.07.012