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Differences in the mode of presentation for acute coronary syndrome by pre-hospitalization medication, in relation to coronary risk factors, East-Osaka acute coronary syndrome (EACS) registry.
- Source :
-
Atherosclerosis [Atherosclerosis] 2011 Nov; Vol. 219 (1), pp. 355-60. Date of Electronic Publication: 2011 Jul 30. - Publication Year :
- 2011
-
Abstract
- Background: Pre-hospitalization medication such as aspirin and nitrates has been shown to affect the mode of presentation in acute coronary syndrome (ACS). However, it is not formally assessed whether other cardiovascular medications may be contributed to the differences in the mode of presentation, especially in relation to coronary risk factors.<br />Methods and Results: We conducted a registration study of patients (M/F 850/323) with either ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) or unstable angina (UA), and examined the differences in the mode of presentation, pre-hospitalization medication, and coronary risk factors. The ratio of the incidence of STEMI and NSTEMI/UA was significantly reduced in patients having pre-hospitalization medication with aspirin, nitrates or statins, but not with other medications such as beta-blockers in multivariate analysis. Pre-hospitalization medication with aspirin and nitrates was significantly associated with the same reduction of the ratio in patients with male gender, hypertension, diabetes mellitus and a history of coronary artery disease. However, in patients who smoked, were obese and hypercholesterolemic, pre-hospitalization medication with nitrates was significantly associated with the reduced ratio. The ratio was significantly low in patients with males and hypercholesterolemia treated with statins before admission.<br />Conclusion: Depending on their coronary risk factors, pre-hospitalization medication with aspirin, nitrates or statins was associated with a different presentation and evolution of ACS.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adrenergic beta-Antagonists therapeutic use
Aged
Angina, Unstable drug therapy
Aspirin therapeutic use
Coronary Artery Disease diagnosis
Coronary Artery Disease drug therapy
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Male
Middle Aged
Myocardial Infarction drug therapy
Nitro Compounds therapeutic use
Obesity complications
Prospective Studies
Registries
Risk Factors
Smoking adverse effects
Acute Coronary Syndrome diagnosis
Acute Coronary Syndrome drug therapy
Angina, Unstable diagnosis
Hospitalization
Myocardial Infarction diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 219
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 21851942
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2011.07.107