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Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.
- Source :
-
Antiviral research [Antiviral Res] 2011 Nov; Vol. 92 (2), pp. 369-71. Date of Electronic Publication: 2011 Aug 11. - Publication Year :
- 2011
-
Abstract
- Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-9096
- Volume :
- 92
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Antiviral research
- Publication Type :
- Academic Journal
- Accession number :
- 21854808
- Full Text :
- https://doi.org/10.1016/j.antiviral.2011.08.003