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Interaction of specialized cardiac conduction system with antiarrhythmic drugs: a simulation study.
- Source :
-
IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2011 Dec; Vol. 58 (12), pp. 3475-8. Date of Electronic Publication: 2011 Aug 18. - Publication Year :
- 2011
-
Abstract
- The use of antiarrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are promising tools that could be used to investigate the effects of specific drugs on cardiac electrophysiology. In this paper, we study the multiscale effects of dofetilide, a drug that blocks IKr, from cellular to organ level paying special attention to its effect on heart structures, in particular the specialized cardiac conduction system (CCS). We include a model of the CCS in a patient-specific anatomical ventricular model and study the drug effects in simulations with and without a CCS. Results confirmed the expected effects of dofetilide at cellular level, increasing the action potential duration, and at organ level, prolonging the QT segment. Notable differences are shown between models with and without the CCS on action potential duration distributions. These techniques show the importance of heart heterogeneity and the global effects of the interaction of drugs with cardiac structures.
- Subjects :
- Action Potentials drug effects
Action Potentials physiology
Computer Simulation
Diffusion Tensor Imaging
Drug Design
Electrocardiography
Heart Conduction System anatomy & histology
Heart Conduction System physiology
Heart Ventricles drug effects
Humans
Phenethylamines pharmacology
Sulfonamides pharmacology
Anti-Arrhythmia Agents pharmacology
Heart Conduction System drug effects
Models, Cardiovascular
Subjects
Details
- Language :
- English
- ISSN :
- 1558-2531
- Volume :
- 58
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- IEEE transactions on bio-medical engineering
- Publication Type :
- Academic Journal
- Accession number :
- 21859609
- Full Text :
- https://doi.org/10.1109/TBME.2011.2165213