Back to Search
Start Over
Standardized flavonoid-rich Eugenia jambolana seed extract retards in vitro and in vivo LDL oxidation and expression of VCAM-1 and P-selectin in atherogenic rats.
- Source :
-
Cardiovascular toxicology [Cardiovasc Toxicol] 2012 Mar; Vol. 12 (1), pp. 73-82. - Publication Year :
- 2012
-
Abstract
- The present inventory evaluates anti-atherogenic potential of flavonoid-rich Eugenia jambolana seed extract (EJSE) against in vitro low-density lipoprotein (LDL) oxidation, foam cell formation, and atherogenic (ATH) diet-induced experimental atherosclerosis in rats. EJSE was able to prevent in vitro LDL oxidation and oxidized LDL-induced macrophage foam cell formation. Also, EJSE supplementation to ATH rats significantly minimized increment in serum markers of LDL oxidation. The ex vivo oxidation indices were also minimized in LDL of EJSE-treated animals. Microscopic evaluation of thoracic aorta of ATH + EJSE rats recorded minimal evidence of atheromatous plaque formation, accumulation of lipid laden macrophages, calcium deposition, and expression of cell adhesion molecules (vascular cell adhesion molecule-1 and P-selectin). This is the first scientific report that demonstrates anti-atherogenic potential of EJSE and warrants further evaluation at clinical level.
- Subjects :
- Animals
Atherosclerosis prevention & control
Cell Line
Diet, Atherogenic methods
Flavonoids isolation & purification
Flavonoids pharmacology
Gene Expression Regulation
Humans
Lipoproteins, LDL antagonists & inhibitors
Male
Mice
Oxidation-Reduction drug effects
P-Selectin antagonists & inhibitors
Plant Extracts isolation & purification
Plant Extracts pharmacology
Plant Extracts therapeutic use
Rats
Seeds chemistry
Atherosclerosis blood
Flavonoids therapeutic use
Lipoproteins, LDL blood
P-Selectin metabolism
Syzygium chemistry
Vascular Cell Adhesion Molecule-1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0259
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 21863403
- Full Text :
- https://doi.org/10.1007/s12012-011-9140-0