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Vascular endothelial growth factor C as a predictor of early recurrence and poor prognosis of resected stage I non-small cell lung cancer.
- Source :
-
Annals of the Academy of Medicine, Singapore [Ann Acad Med Singap] 2011 Jul; Vol. 40 (7), pp. 319-24. - Publication Year :
- 2011
-
Abstract
- Introduction: Stage I non-small cell lung cancer (NSCLC) is potentially curable after completely resection, but early recurrence may infl uence prognosis. This study hypothesises that vascular endothelial growth factor C (VEGF-C) plays a key role in predicting early recurrence and poor survival of patients with stage I NSCLC.<br />Materials and Methods: The expression of VEGF-C was immuno-histochemically (IHC) analysed in tumour samples of primary stage I NSCLC and correlated to early recurrence (< 36 months), disease-free survival, and overall survival in all 49 patients.<br />Results: Early recurrence was identifi ed in 16 patients (33%), and the early recurrence rate in strong and weak VEGF-C activity was significantly different (P = 0.016). VEGF-C was also an independent risk factor in predicting early recurrence (HR = 3.98, P = 0.02). Patients with strong VEGF-C staining also had poor 3-year disease-free survival (P = 0.008) and overall survival (P = 0.007).<br />Conclusion: Strong VEGF-C IHC staining could be a biomarker for predicting early recurrence and poor prognosis of resected stage I NSCLC, if the results of the present study are confirmed in a larger study. A more aggressive adjuvant therapy should be used in this group of patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers blood
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Non-Small-Cell Lung surgery
Disease-Free Survival
Female
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Staging
Prognosis
Survival Analysis
Taiwan
Vascular Endothelial Growth Factor A blood
Carcinoma, Non-Small-Cell Lung blood
Carcinoma, Non-Small-Cell Lung mortality
Vascular Endothelial Growth Factor A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2972-4066
- Volume :
- 40
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Annals of the Academy of Medicine, Singapore
- Publication Type :
- Academic Journal
- Accession number :
- 21870023