Cortical bone resorption rate in elderly persons: estimates from long-term in vivo measurements of (90)Sr in the skeleton.

The rate of cortical bone resorption was assessed from long-term in vivo measurements of (90)Sr content in the skeleton for men aged 50-80 years and for women 0-30 years after menopause. Measurements of (90)Sr were conducted with a whole body counter (WBC) for residents of the Techa Riverside communities (Southern Urals, Russia), who ingested large amounts of (90)Sr as a result of releases of liquid radioactive wastes into the river from the Mayak plutonium facility in early 1950s. The results of this study showed an increase in the rate of cortical bone resorption in both men and women, as based on the use of accidentally ingested (90)Sr as a tracer for bone metabolism. In men there was a continuous gradual increase in the rate of cortical bone resorption after 55 years from 2.8 to 4.5%/year by the age of 75 years. In women, there was a doubled increase in the rate of cortical bone resorption after menopause of up to 6%/year; then the rate remained unchanged for 10-12 years with a subsequent gradual decline down to 5-5.5%/year. Comparison of the rate of cortical bone resorption in men and women older than 55 years showed that women expressed significantly higher levels of cortical bone resorption.
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