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In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides.
- Source :
-
Cellular immunology [Cell Immunol] 2011; Vol. 271 (2), pp. 299-307. Date of Electronic Publication: 2011 Jul 29. - Publication Year :
- 2011
-
Abstract
- Thymosin-β4 (Tβ4) is a G-actin sequestering peptide involved in regeneration and remodeling of injured tissues. In this work, we have designed and synthesized three peptide sequences containing the N-terminus (TYB4-n), the central part (TYB4-i) or the C-terminus (TYB4-c) of Tβ4. All fragments are overlapping on the main central binding actin site. After a structural characterization, we have evaluated in vitro and in vivo their pro-angiogenic effects. The results of this study have shown that: (i) each fragment reproduces the native conformation; (ii) Tβ4-derived peptides exert both in vitro and in vivo pro-angiogenic effects; (iii) their in vitro effect seem to be related to the activation of several signaling pathways and is positively modulated by the N-terminus of Tβ4.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Amino Acid Sequence
Angiogenesis Inducing Agents chemistry
Animals
Cell Proliferation drug effects
Chick Embryo
Human Umbilical Vein Endothelial Cells
Humans
In Vitro Techniques
Models, Molecular
Molecular Sequence Data
Neovascularization, Physiologic physiology
Peptide Fragments chemical synthesis
Peptide Fragments chemistry
Peptide Fragments genetics
Peptide Fragments pharmacology
Protein Conformation
Signal Transduction drug effects
Thymosin chemistry
Thymosin genetics
Thymosin physiology
Wound Healing drug effects
Wound Healing physiology
Angiogenesis Inducing Agents pharmacology
Neovascularization, Physiologic drug effects
Thymosin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2163
- Volume :
- 271
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cellular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21872226
- Full Text :
- https://doi.org/10.1016/j.cellimm.2011.07.008