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Anti-hepatitis B virus and cytotoxic diterpenoids from Isodon lophanthoides var. gerardianus.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2011; Vol. 59 (9), pp. 1102-5. - Publication Year :
- 2011
-
Abstract
- Four new diterpenoides, isolophanthins A-D (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.
- Subjects :
- Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic toxicity
Antiviral Agents isolation & purification
Antiviral Agents toxicity
Cell Line, Tumor
Diterpenes isolation & purification
Diterpenes toxicity
Drug Screening Assays, Antitumor
Hepatitis B Surface Antigens drug effects
Hepatitis B e Antigens drug effects
Humans
Magnetic Resonance Spectroscopy
Plant Components, Aerial chemistry
Antineoplastic Agents, Phytogenic chemistry
Antiviral Agents chemistry
Diterpenes chemistry
Hepatitis B virus drug effects
Isodon chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5223
- Volume :
- 59
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 21881252
- Full Text :
- https://doi.org/10.1248/cpb.59.1102