Back to Search
Start Over
Flavusides A and B, antibacterial cerebrosides from the marine-derived fungus Aspergillus flavus.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2011; Vol. 59 (9), pp. 1174-7. - Publication Year :
- 2011
-
Abstract
- Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 μg/ml for S. aureus and 31.2 μg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 μg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 μg/ml for multidrug-resistant S. aureus.
- Subjects :
- Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Aquatic Organisms microbiology
Cerebrosides isolation & purification
Cerebrosides pharmacology
Drug Resistance, Bacterial drug effects
Glycosphingolipids isolation & purification
Glycosphingolipids pharmacology
Magnetic Resonance Spectroscopy
Methicillin-Resistant Staphylococcus aureus drug effects
Microbial Sensitivity Tests
Molecular Conformation
Staphylococcus aureus drug effects
Tandem Mass Spectrometry
Anti-Bacterial Agents chemistry
Aspergillus flavus chemistry
Cerebrosides chemistry
Glycosphingolipids chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5223
- Volume :
- 59
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 21881265
- Full Text :
- https://doi.org/10.1248/cpb.59.1174