Back to Search
Start Over
[Correlation between TGF- β1 expression and Treg cell infiltration in glioma].
- Source :
-
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2011 Jun; Vol. 27 (6), pp. 680-2. - Publication Year :
- 2011
-
Abstract
- Aim: To investigate correlation between the expression of TGF-β1 and the amount of Treg cell in glioma, and evaluate their clinical values in predicting the prognosis of glioma.<br />Methods: Double immunohistochemistry staining was used to detect the expression of TGF-β1, CD4 and Foxp3 in 135 specimens of human gliomas (WHO I 18, WHO II 45, WHO III 53, WHO IV 19) and 15 normal brain.<br />Results: OF the 135 specimans of glioma, 58 showed low TGF-β1 expression and 77 (57.03%) showed high TGF-β1 expression while ws not expression in normal brain tissue. Average Treg cell density in glioma was 2. 031/HP, but there was no expression of Treg in normal brain tissue. Expression of TGF-β1 was positively correlated with the mount of Treg in glioma tissues (r = 0.294, P < 0.01). Compared with the low grade, The levels of TGF-β1 and the amount of Treg cells with significant higher in high-grade glioma, however the mount of Treg had no correlations with Sex, KPS score. The Laplan-Meier analysis showed that there wer significant difference in overall survival (OS) between the TGF-β1 high-expression and low-expression group (P < 0.001). Cox multivariate analysis showed that TGF-β1 and Treg were not independent prognostic factors (P > 0.05).<br />Conclusion: Intratumoral of TGF-β1 may relate to the infiltration of Treg cells in glioma tissues. The level of TGF-β1 was obviously increased in high grade. Glioma patients with TGF-β1 or Trg high expression have poorer prognosis, while TGF-β1 and Treg cannot serve as independent prognostic factors of glioma survival time.
- Subjects :
- Adolescent
Adult
Aged
CD4 Antigens metabolism
Child
Child, Preschool
Female
Forkhead Transcription Factors metabolism
Humans
Lymphocytes, Tumor-Infiltrating metabolism
Lymphocytes, Tumor-Infiltrating pathology
Male
Middle Aged
Neoplasm Staging
Prognosis
Survival Analysis
T-Lymphocytes, Regulatory immunology
Brain Neoplasms metabolism
Brain Neoplasms pathology
Glioma metabolism
Glioma pathology
T-Lymphocytes, Regulatory metabolism
T-Lymphocytes, Regulatory pathology
Transforming Growth Factor beta1 metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1007-8738
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21882476