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Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.

Authors :
Vázquez-Higuera JL
Mateo I
Sánchez-Juan P
Rodríguez-Rodríguez E
Pozueta A
Calero M
Dobato JL
Frank-García A
Valdivieso F
Berciano J
Bullido MJ
Combarros O
Source :
BMC research notes [BMC Res Notes] 2011 Sep 07; Vol. 4, pp. 327. Date of Electronic Publication: 2011 Sep 07.
Publication Year :
2011

Abstract

Background: Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases.<br />Methods: In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variation that might influence AD risk.<br />Results: There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele.<br />Conclusion: Our negative findings in the Spanish population argue against the hypothesis that genetic variation in the tau protein phosphatase-2A (PP2A) pathway is causally related to AD risk.

Details

Language :
English
ISSN :
1756-0500
Volume :
4
Database :
MEDLINE
Journal :
BMC research notes
Publication Type :
Academic Journal
Accession number :
21899770
Full Text :
https://doi.org/10.1186/1756-0500-4-327