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Screening for unrecognized coeliac disease in subfertile couples.
- Source :
-
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2011 Dec; Vol. 46 (12), pp. 1423-8. Date of Electronic Publication: 2011 Sep 12. - Publication Year :
- 2011
-
Abstract
- Objective: Subfertility has been reported as a long-term complication of unrecognized and/or untreated coeliac disease (CD); however, the results from studies on this topic are ambiguous. We aimed to determine the prevalence of unrecognized CD in subfertile male-female couples visiting a fertility clinic compared with the general population.<br />Methods: Subjects included 1038 male-female couples (n = 2076) who visited the fertility clinic of the Leiden University Medical Center in the Netherlands between 2003 and 2009. All consecutive patients were routinely, serologically screened, and those with positive test results for antibodies against IgA anti-tissue transglutaminase type 2 and IgA endomysial antibodies were considered to have unrecognized CD. Clinical data on gender, age, height, weight, diagnosis of subfertility, and previously diagnosed CD were collected from the clinical files. Subsequently, after serological screening, all patients were anonymized. The prevalence of unrecognized CD was compared with the one in the general adult population in the Netherlands (0.35%).<br />Results: The prevalence of unrecognized CD in subfertile male-female couples was 0.48% (10/2076; 6 females and 4 males) and was not significantly more frequent compared with the general population. Compared with the control group, similar CD prevalences were found within the different subfertility categories separately: unexplained subfertility, anovulation, tubal pathology, and male factor (p = NS).<br />Conclusion: In our large study cohort of subfertile male-female couples, the prevalence of unrecognized CD is comparable to the general population in the Netherlands. No association was observed between CD and subfertility in the different subfertility categories and genders.
- Subjects :
- Adult
Anovulation complications
Anovulation epidemiology
Antibodies blood
Celiac Disease complications
Fallopian Tube Diseases complications
Fallopian Tube Diseases epidemiology
Female
GTP-Binding Proteins immunology
Humans
Immunoglobulin A immunology
Infertility complications
Infertility, Male complications
Infertility, Male epidemiology
Male
Mass Screening
Middle Aged
Netherlands epidemiology
Prevalence
Protein Glutamine gamma Glutamyltransferase 2
Retrospective Studies
Transglutaminases immunology
Young Adult
Celiac Disease diagnosis
Celiac Disease epidemiology
Infertility epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1502-7708
- Volume :
- 46
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 21905980
- Full Text :
- https://doi.org/10.3109/00365521.2011.615858