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The role of hepatitis B immunoglobulin in hepatitis B related liver transplantation: Canadian Transplant Centre Position Paper.
- Source :
-
Annals of hepatology [Ann Hepatol] 2011 Oct-Dec; Vol. 10 (4), pp. 441-4. - Publication Year :
- 2011
-
Abstract
- Introduction: Hepatitis B virus (HBV) related liver transplant (LT) recipients face a high risk of HBV reinfection in the absence of continuous post-operative HBV prophylaxis. Combination HBV prophylaxis with hepatitis B immune globulin (HBIg) and nucleos(t)ide anti-viral agents prevents HBV recurrence in 90 to 100% of patients who undergo transplantation for hepatitis B and is considered the standard of care in Canada. Post liver transplant HBV prophylaxis protocols vary with regard to the dosing, duration and routes of HBIg administration. All Canadian transplant centres managing liver transplant patients were surveyed as to their HBV transplant protocols.<br />Results: Results of the survey showed that the majority of the Canadian transplant centres use an oral antiviral in combination with long term or indefinite HBIg for prevention of HBV recurrence post liver transplantation. Studies were done to test new protocols using lower HBIg doses given intramuscularly or subcutaneously alone or in combination with antiviral agents. <br /> Conclusion. Long term HBIg administration post transplantation in combination with antiviral agents is an integral part of Canadian HBV related liver transplant protocol. <br />
- Subjects :
- Administration, Oral
Canada
Drug Administration Schedule
Drug Therapy, Combination
Health Care Surveys
Humans
Secondary Prevention
Time Factors
Treatment Outcome
Antiviral Agents administration & dosage
Hepatitis B drug therapy
Hepatitis B surgery
Immunoglobulins administration & dosage
Liver Transplantation standards
Standard of Care
Subjects
Details
- Language :
- English
- ISSN :
- 1665-2681
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annals of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 21911883