Back to Search
Start Over
[Irinotecan as second-line chemotherapy for 5-FU-resistant gastric cancer with disseminated intravascular coagulation: a case report].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2011 Sep; Vol. 38 (9), pp. 1517-20. - Publication Year :
- 2011
-
Abstract
- A 60-year-old female was diagnosed as advanced gastric cancer with multiple bone, neck and mediastinal lymph node metastases. As a primary chemotherapy, she was treated with S-1(50 m g/body, twice daily for 4 weeks, followed by a 2- week rest). After 3 courses of S-1, she developed a disease progression with pulmonary lymphangitic carcinomatosis and disseminated intravascular coagulation(DIC). Therefore, she received second-line chemotherapy of irinotecan(CPT-11 150 mg/m2, biweekly). Within 3 weeks of starting the treatment, the clinical and laboratory signs of DIC were dramatically resolved. There have been no previous reports of irinotecan alone showing such remarkable effectiveness in a patient with 5- FU-resistant gastric cancer with DIC.
- Subjects :
- Camptothecin therapeutic use
Fatal Outcome
Female
Fluorouracil therapeutic use
Humans
Irinotecan
Middle Aged
Neoplasm Staging
Stomach Neoplasms complications
Stomach Neoplasms pathology
Antineoplastic Agents, Phytogenic therapeutic use
Camptothecin analogs & derivatives
Disseminated Intravascular Coagulation complications
Salvage Therapy
Stomach Neoplasms drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 38
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 21918353