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Direct measurement of gastroesophageal reflux episodes in patients with squamous cell carcinoma by 24-h pH-impedance monitoring.
- Source :
-
The American journal of gastroenterology [Am J Gastroenterol] 2011 Nov; Vol. 106 (11), pp. 1923-9. Date of Electronic Publication: 2011 Sep 20. - Publication Year :
- 2011
-
Abstract
- Objectives: Recent studies have consistently reported a significant association between gastric atrophy and esophageal squamous cell carcinomas (ESCCs). However, causative factors responsible for the linkage remain to be clarified. Multichannel intraluminal impedance monitoring in conjunction with a pH sensor (MII-pH) is a reliable technique to evaluate gastroesophageal reflux (GER) episodes, independent of the acidity. We investigated the potential roles of GER in the pathogenesis of ESCC with MII-pH.<br />Methods: From August 2008 to May 2010, 14 consecutive inpatients with superficial ESCCs (ESCC group) and 14 age- and sex-matched inpatients without any esophageal dysplastic lesions (non-ESCC group) were enrolled. Twenty-four hour portable MII-pH monitoring was performed under standard hospitalized conditions. The data of MII-pH were used to identify acid reflux (AR: pH drop below 4.0 during a reflux episode) and non-AR (NAR: pH drop above 4.0 during a reflux episode).<br />Results: The median intragastric pH of the ESCC group was 4.7 (2.3-6.4), implying hypochlorhydria in this patient group. The numbers of total reflux and NAR episodes in the ESCC group were significantly higher than those in the non-ESCC group (56 (43-87) vs. 35.5 (18-47), P=0.016 for total reflux and 46.5 (32-84) vs. 24.5 (8-37), P=0.012 for NAR), whereas the numbers of AR were similar in both groups. In addition, there was significance in the category of percentage time of bolus reflux episodes.<br />Conclusions: Using MII-pH monitoring, we revealed the clinical significance of GER, especially NAR, in ESCCs. NAR may be a key factor in the link between gastric atrophy and ESCCs.
- Subjects :
- Aged
Aged, 80 and over
Carcinoma, Squamous Cell physiopathology
Electric Impedance
Esophageal Neoplasms physiopathology
Gastric Acid chemistry
Gastric Acidity Determination
Gastritis, Atrophic complications
Gastroesophageal Reflux complications
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Monitoring, Physiologic
Statistics, Nonparametric
Carcinoma, Squamous Cell etiology
Esophageal Neoplasms etiology
Gastritis, Atrophic physiopathology
Gastroesophageal Reflux physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1572-0241
- Volume :
- 106
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The American journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 21931379
- Full Text :
- https://doi.org/10.1038/ajg.2011.282