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Mechanisms and interventions in peritoneal fibrosis.
- Source :
-
Clinical and experimental nephrology [Clin Exp Nephrol] 2012 Feb; Vol. 16 (1), pp. 109-14. Date of Electronic Publication: 2011 Sep 21. - Publication Year :
- 2012
-
Abstract
- Peritoneal dialysis (PD) is an attractive treatment for patients with end-stage kidney disease (ESKD). However, long-term peritoneal dialysis is associated with development of functional and structural alterations of the peritoneal membrane. Several factors are implicated in the development of peritoneal fibrosis in PD patients. Inflammatory cytokines, which are induced in the peritoneal cavity during peritonitis, may also induce chronic inflammation and fibrosis. Transforming growth factor β1 (TGF-β1) is generally considered to play an important role in peritoneal fibrosis. The objective of this review is to summarize the mechanisms of peritoneal fibrosis using in vitro and in vivo studies, and the current status and future prospects of interventions in the peritoneal fibrosis.
- Subjects :
- Angiotensin Receptor Antagonists therapeutic use
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Animals
Epithelial Cells transplantation
Epithelium transplantation
Glycation End Products, Advanced adverse effects
Guanidines therapeutic use
Humans
Kidney Failure, Chronic therapy
Peritoneal Fibrosis prevention & control
Phenyl Ethers therapeutic use
Pyridoxamine therapeutic use
Renin-Angiotensin System drug effects
Renin-Angiotensin System physiology
Vascular Endothelial Growth Factor A antagonists & inhibitors
ortho-Aminobenzoates therapeutic use
Peritoneal Dialysis adverse effects
Peritoneal Fibrosis drug therapy
Peritoneal Fibrosis etiology
Peritoneum pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7799
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 21935614
- Full Text :
- https://doi.org/10.1007/s10157-011-0533-y