Low genetic diversity of Pneumocystis jirovecii among Cuban population based on two-locus mitochondrial typing.

Authors :: de Armas Y
Friaza V
Capó V
Durand-Joly I
Govín A
de la Horra C
Dei-Cas E
Calderón EJ
Source :: Medical mycology [Med Mycol] 2012 May; Vol. 50 (4), pp. 417-20. Date of Electronic Publication: 2011 Sep 22.
Publication Year :: 2012
Abstract: Genotypes of two different loci of the Pneumocystis jirovecii mitochondrial gene were studied in specimens from a total of 75 Pneumocystis pneumonia patients in Spain, France and Cuba. A new genotype of the mitochondrial small subunit rRNA gene of P. jirovecii (160A/196T) was identified, which was revealed to be the most common in these three countries, especially in Cuba where its proportion reached 93.8%. Our data imply that the new genotype might be circulating worldwide and also suggests that the distribution of P. jirovecii genotypes could be narrower in islands such as Cuba.

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