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Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2011 Sep 26; Vol. 50 (40), pp. 9496-500. Date of Electronic Publication: 2011 Aug 25. - Publication Year :
- 2011
- Subjects :
- Angiogenesis Inhibitors metabolism
Integrin alphaVbeta3 chemistry
Methylation
Molecular Dynamics Simulation
Nuclear Magnetic Resonance, Biomolecular
Peptide Library
Peptides, Cyclic chemistry
Protein Conformation
Receptors, Vitronectin chemistry
Structure-Activity Relationship
Angiogenesis Inhibitors chemistry
Angiogenesis Inhibitors pharmacology
Integrin alphaVbeta3 metabolism
Snake Venoms chemistry
Snake Venoms metabolism
Snake Venoms pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 50
- Issue :
- 40
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 21948451
- Full Text :
- https://doi.org/10.1002/anie.201102971