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Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro.
- Source :
-
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2011 Oct; Vol. 344 (10), pp. 675-83. Date of Electronic Publication: 2011 Aug 29. - Publication Year :
- 2011
-
Abstract
- A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by (1) H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549.<br /> (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Survival drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Pyrimidines chemistry
Pyrimidines pharmacology
Structure-Activity Relationship
Thiazoles chemistry
Thiazoles pharmacology
Antineoplastic Agents chemical synthesis
Drug Design
Pyrimidines chemical synthesis
Thiazoles chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4184
- Volume :
- 344
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archiv der Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 21984017
- Full Text :
- https://doi.org/10.1002/ardp.201000238