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Anti-inflammatory activity of alkaloids: an update from 2000 to 2010.

Authors :
Souto AL
Tavares JF
da Silva MS
Diniz Mde F
de Athayde-Filho PF
Barbosa Filho JM
Source :
Molecules (Basel, Switzerland) [Molecules] 2011 Oct 11; Vol. 16 (10), pp. 8515-34. Date of Electronic Publication: 2011 Oct 11.
Publication Year :
2011

Abstract

Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.

Subjects

Subjects :
Alkaloids adverse effects
Alkaloids therapeutic use
Animals
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Humans
Inflammation drug therapy
Isoquinolines adverse effects
Isoquinolines pharmacology
Isoquinolines therapeutic use
Plant Extracts adverse effects
Plant Extracts therapeutic use
Alkaloids pharmacology
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Inflammation Mediators pharmacology
Plant Extracts pharmacology

Details

Language :
English
ISSN :
1420-3049
Volume :
16
Issue :
10
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
21989312
Full Text :
https://doi.org/10.3390/molecules16108515
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