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Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise.
- Source :
-
European journal of nutrition [Eur J Nutr] 2012 Oct; Vol. 51 (7), pp. 791-9. Date of Electronic Publication: 2011 Oct 12. - Publication Year :
- 2012
-
Abstract
- Background: Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators.<br />Aim: The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q(10) (CoQ(10)) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise.<br />Methods: The participants were classified in two groups: CoQ(10) group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing.<br />Results: Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ(10) during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ(10) prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ(10) supplementation reduced creatinine production.<br />Conclusions: CoQ(10) supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.
- Subjects :
- 8-Hydroxy-2'-Deoxyguanosine
Administration, Oral
Adult
Antioxidants metabolism
Athletes
Catalase metabolism
Deoxyguanosine analogs & derivatives
Deoxyguanosine blood
Humans
Inflammation Mediators antagonists & inhibitors
Inflammation Mediators metabolism
Interleukin-6 blood
Isoprostanes blood
Male
Signal Transduction drug effects
Tumor Necrosis Factor-alpha blood
Ubiquinone administration & dosage
Dietary Supplements
Inflammation drug therapy
Oxidative Stress drug effects
Running physiology
Ubiquinone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1436-6215
- Volume :
- 51
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 21990004
- Full Text :
- https://doi.org/10.1007/s00394-011-0257-5