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Lymphocyte subtypes CD3+, CD19+, CD16+CD56+, CD4+, CD8+, and CD3+HLA-DR+ in peripheral blood obtained from patients after thoracic organ transplantation.
- Source :
-
Transplantation proceedings [Transplant Proc] 2011 Oct; Vol. 43 (8), pp. 3055-7. - Publication Year :
- 2011
-
Abstract
- Introduction: The aim of this study was to assess peripheral blood lymphocyte subtypes (CD3+, CD19+, CD16+CD56+, CD4+, CD8+, and CD3+HLA-DR+) obtained from thoracic organ recipients at various periods after transplantation.<br />Material and Methods: Seventeen patients after lung transplantation (LT) and 5 patients after heart transplantation (HT) included 13 males (76.5%) and 4 females (23.5%) of overall mean age at the time of transplantation of 46.7±11.55 years and mean body mass index of 21.1±4. Lymphocyte phenotypes were estimated using Simultest IMK Plus.<br />Results: A significant decrease in lymphocytes of the majority of subtypes was observed at 1 year posttransplantation compared with normal ranges: CD19+ B lymphocytes in 56% of patients, CD8+ T cells among 48% and CD16+CD56+ natural killer elements, 56%. In contrast, there were increased numbers of activated lymphocytes (CD3+HLA-DR+). Beyond the 1-year observation, we observed a trend to normalize parameters among the majority of subjects.<br />Conclusion: A clear tendency to a decrease number of peripheral blood lymphocytes of various subtypes was observed among thoracic organ recipients in the first year posttransplantation with the exception of activated HLA-DR+ cells. After the first year, there was slow restoration of lymphocytes.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Cytomegalovirus Infections blood
Cytomegalovirus Infections immunology
Female
Graft Rejection blood
Graft Rejection immunology
HLA-DR Antigens blood
Humans
Lymphopenia etiology
Lymphopenia immunology
Male
Middle Aged
Postoperative Complications blood
Postoperative Complications immunology
Time Factors
Transplantation Immunology
Heart Transplantation adverse effects
Heart Transplantation immunology
Lung Transplantation adverse effects
Lung Transplantation immunology
Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 21996223
- Full Text :
- https://doi.org/10.1016/j.transproceed.2011.09.001