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Paradox of advanced glycation end-products in late cardiac biopsies of heart transplant recipients.
- Source :
-
Transplantation proceedings [Transplant Proc] 2011 Oct; Vol. 43 (8), pp. 3058-60. - Publication Year :
- 2011
-
Abstract
- Background: A pilot study of orthotopic heart transplant (OHT) recipients showed that advanced glycation end-product (AGE) deposits were related to acute rejection episodes among subjects with diabetes mellitus (DM); in contrast, among non-DM patients it was associated with prolonged freedom from coronary artery vasculopathy (CAV). However the number of observations in non-diabetic subjects was low. The aim of the current study was to establish the role of AGEs in late endomyocardial biopsies (EMBs) among a larger group of non-diabetic patients.<br />Material and Methods: Elective EMBs were performed at 3 years post OHT in 62 subjects with DM, namely, 57 males and 5 females of overall mean age of 50±8 years versus 92 free of DM, including 79 males and 13 females of mean age 51±13 years. We localized AGEs in myocardial paraffin sections using monoclonal mouse anti-AGE antibodies. The presence of AGEs in cardiomyocytes, stromal cells, capillaries, and arterioles was described with a semiquantitative scale.<br />Results: All-cause deaths, CAV, and CAV-related events were observed in 28% versus 23%, 27% versus 29%, and 15% versus 19% of non-DM versus DM patients (P=NS). The occurrence of AGEs was significantly more frequent among non-DM than DM subjects: cardiocytes, 100% versus 69% (P<.0001); stroma, 54% versus 31% (P=.0037); capillaries, 67% versus 31% (P<.0001); and arterioles, 26% versus 3% (P=.0002; chi-square). Among the DM group, mean EMB score correlated with AGE presence in cardiomyocytes (n=0.29; P<.05, Spearman test) AGE presence had no impact on survival or CAV development.<br />Conclusion: AGE presence was more common in late EMB from non-diabetic than diabetic OHT recipients; they had no impact on survival or CAV in non-diabetic patients.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Biopsy
Coronary Artery Disease metabolism
Coronary Artery Disease pathology
Diabetes Complications metabolism
Diabetes Complications pathology
Female
Graft Rejection metabolism
Graft Rejection pathology
Humans
Male
Middle Aged
Time Factors
Glycation End Products, Advanced metabolism
Heart Transplantation pathology
Heart Transplantation physiology
Myocardium metabolism
Myocardium pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 21996224
- Full Text :
- https://doi.org/10.1016/j.transproceed.2011.08.036