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Individual psychomotor impairment in relation to zopiclone and ethanol concentrations in blood--a randomized controlled double-blinded trial.
- Source :
-
Addiction (Abingdon, England) [Addiction] 2012 May; Vol. 107 (5), pp. 925-32. Date of Electronic Publication: 2012 Feb 11. - Publication Year :
- 2012
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Abstract
- Aims: To investigate individual traffic-relevant impairment related to measured blood zopiclone and ethanol concentrations. Also, we aimed to study possible development of acute tolerance.<br />Design: A randomized controlled four-way cross-over double-blind trial. Study drugs were zopiclone 5 or 10 mg, 50 g ethanol or placebo.<br />Setting: Laboratory study with computerized tests: Connor's Continuous Performance test, Choice Reaction Time and Stockings of Cambridge. Altogether, the tests consisted of 15 test components, representing three levels of behaviour (automotive, control, executive planning), relevant to traffic safety.<br />Participants: Sixteen healthy male volunteers.<br />Measurements: Each study day, 10 blood samples were collected from each volunteer. Fifteen psychomotor test components were registered at baseline and a further three times after intake. Impairment was defined as any individual deterioration in performance compared to individual baseline performance.<br />Findings: Blood drug concentrations up to 74 µg/l zopiclone and 0.100% ethanol were measured. We found a clear positive concentration-effect relationship for zopiclone and ethanol for both automotive and control behaviours, and a modest relationship for executive planning behaviour. Significant impairment started to be observed at concentrations above 16 µg/l zopiclone (automotive and control behaviour) and above 0.026% ethanol (automotive behaviour). Acute tolerance was found for both drugs.<br />Conclusions: The hypnotic, zopiclone, can impair psychomotor performance at blood concentrations as low as 16 µg/l.<br /> (© 2011 The Authors, Addiction © 2011 Society for the Study of Addiction.)
- Subjects :
- Automobile Driving
Azabicyclo Compounds adverse effects
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Ethanol adverse effects
Humans
Hypnotics and Sedatives adverse effects
Male
Piperazines adverse effects
Psychomotor Disorders chemically induced
Psychomotor Performance drug effects
Azabicyclo Compounds blood
Ethanol blood
Hypnotics and Sedatives blood
Piperazines blood
Psychomotor Disorders blood
Subjects
Details
- Language :
- English
- ISSN :
- 1360-0443
- Volume :
- 107
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Addiction (Abingdon, England)
- Publication Type :
- Academic Journal
- Accession number :
- 22008377
- Full Text :
- https://doi.org/10.1111/j.1360-0443.2011.03693.x