Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells.

Authors :: Cameron P
Paton N
Smith DG
Source :: Journal of comparative pathology [J Comp Pathol] 2012 Jul; Vol. 147 (1), pp. 20-3. Date of Electronic Publication: 2011 Oct 19.
Publication Year :: 2012
Abstract: The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Cattle
Host-Pathogen Interactions
Humans
Leukocytes, Mononuclear enzymology
Species Specificity
Tumor Necrosis Factor-alpha metabolism
Enzyme Activation drug effects
Extracellular Signal-Regulated MAP Kinases biosynthesis
Leukocytes, Mononuclear drug effects
Shiga Toxin 2 toxicity
p38 Mitogen-Activated Protein Kinases biosynthesis

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