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Radiation dosimetry estimates of [18F]-fluoroacetate based on biodistribution data of rats.
- Source :
-
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2012 Jan; Vol. 70 (1), pp. 332-5. Date of Electronic Publication: 2011 Oct 13. - Publication Year :
- 2012
-
Abstract
- We estimated the dosimetry of [(18)F]fluoroacetate (FAC) with the method established by MIRD based on biodistribution data of rats. We selected some important organs and computed their residence time, their absorbed doses and effective dose with the (%ID(Organ)) (human) data using OLINDA/EXM 1.1 program. We observed the highest absorbed doses in the heart wall (0.025mGy/MBq) and the lowest in skin (0.0079mGy/MBq). The total mean absorbed doses and the effective doses were 0.011mGy/MBq and 0.014mSv/MBq, respectively. A 370-MBq injection of FAC leads to an estimated effective dose of 5.2mSv. The potential radiation risk associated with FAC/PET imaging is well within the accepted limits.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-9800
- Volume :
- 70
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22019094
- Full Text :
- https://doi.org/10.1016/j.apradiso.2011.09.025