Radiation dosimetry estimates of [18F]-fluoroacetate based on biodistribution data of rats.

Authors :: Zhang JP
Zhang YJ
Xu JY
Yang ZY
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2012 Jan; Vol. 70 (1), pp. 332-5. Date of Electronic Publication: 2011 Oct 13.
Publication Year :: 2012
Abstract: We estimated the dosimetry of [(18)F]fluoroacetate (FAC) with the method established by MIRD based on biodistribution data of rats. We selected some important organs and computed their residence time, their absorbed doses and effective dose with the (%ID(Organ)) (human) data using OLINDA/EXM 1.1 program. We observed the highest absorbed doses in the heart wall (0.025mGy/MBq) and the lowest in skin (0.0079mGy/MBq). The total mean absorbed doses and the effective doses were 0.011mGy/MBq and 0.014mSv/MBq, respectively. A 370-MBq injection of FAC leads to an estimated effective dose of 5.2mSv. The potential radiation risk associated with FAC/PET imaging is well within the accepted limits.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Body Burden
Computer Simulation
Humans
Male
Metabolic Clearance Rate
Organ Specificity
Radiation Dosage
Radiopharmaceuticals pharmacokinetics
Rats
Species Specificity
Tissue Distribution
Fluoroacetates pharmacokinetics
Models, Biological
Whole-Body Counting methods

Language :: English
ISSN :: 1872-9800
Volume :: 70
Issue :: 1
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 22019094
Full Text :: https://doi.org/10.1016/j.apradiso.2011.09.025

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