Back to Search
Start Over
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2011 Dec 01; Vol. 187 (11), pp. 5500-4. Date of Electronic Publication: 2011 Oct 26. - Publication Year :
- 2011
-
Abstract
- Renal involvement in systemic lupus erythematosus remains a major cause of morbidity and mortality. Although immune parameters that instigate renal damage have been characterized, their link to local processes, which execute tissue damage, is poorly understood. Using genetic-deletion and pharmacological-inhibition approaches, we demonstrated that calcium/calmodulin-dependent protein kinase type IV, which contributes to altered cytokine production in systemic lupus erythematosus patients, controls spontaneous and platelet-derived growth factor-stimulated mesangial cell proliferation and promotes IL-6 production through AP-1. Our studies identified calcium/calmodulin-dependent protein kinase type IV as a valuable treatment target for lupus nephritis and point out the importance of local kidney factors in the expression of tissue damage that, if properly targeted, should enhance clinical benefit and limit toxicity.
- Subjects :
- Animals
Blotting, Western
Electrophoretic Mobility Shift Assay
Enzyme-Linked Immunosorbent Assay
Female
Interleukin-6 biosynthesis
Interleukin-6 immunology
Mice
Mice, Inbred MRL lpr
Reverse Transcriptase Polymerase Chain Reaction
Calcium-Calmodulin-Dependent Protein Kinase Type 4 metabolism
Cell Proliferation
Lupus Nephritis enzymology
Lupus Nephritis pathology
Mesangial Cells enzymology
Mesangial Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 187
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 22031763
- Full Text :
- https://doi.org/10.4049/jimmunol.1102357